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Welcome to Chemical Toxicology and Environmental Fate tool Print

This tool has been specifically developed to help SME users to assess the toxicity, environmental fate and human health effects of their chemicals using freely available non- testing methods such as (Q)SAR.

The TESS team recognized that there is an urgent need to help SMEs to find relevant information and to help them use (Q)SAR to fill the data gaps for their products so as to reduce the cost of REACH registration.

The material and resources available with this tool will help you to understand the process of filling the data gap and to identify the hazard of your chemical being persistant, bioaccumlative and toxic (PBT) using (Q)SAR.


Why do you need to assess the toxicology and environmental fate of your chemical?


To comply with REACH

According to REACH legislation, data on mammalian toxicity, environmental toxicity and environmental fate, including chemical and biotic degradation of your chemical is required for the registration purpose.  Based on this information the status of your chemical can be determined as well as ensuring that humans and the environment are not subjected to any significant risks.


However if you chemical is found to be persistent, bioaccumulative and toxic (PBT), or carcinogenic, mutagenic and toxic to reproduction (CMR) or an endocrine disrupter it must be registered earlier because it will need to be authorised so you need to start planning NOW.                                    

Why is this tool useful?

To reduce cost and time

To be able to assess toxicity animal tests are usually required and these are very expensive.  To reduce costs you will want to find validated toxicity data that has already been obtained on your chemical.  If this is not available you will need to decide whether you need to do animal testing. The easiest, cheapest and fastest way is to assess the toxicity of your chemical is to use a computer based method (such as QSAR).  These methods have been approved to replace animal testing if they meet the REACH guidance on using QSAR. This tool provides some guidelines to SMEs on the freely available (Q)SAR tools and models than can be used to fill your data gap, to assess the environmental impact of your chemical (PBT statue) and to identify the hazard of your chemical being a potential mutagen or endocrine disruptor for REACH purpose. 


How to use this tool?


Depending on your need, you can choose any of the followings, 



This tool will provide a stepwise guide on how to use QSAR methods to fill your data gap and to assesss the environmental impact of your chemical (PBT status). 

Start here if you want to carry out PBT screening of your chemical.


This page provides guidance for using QSAR to assess human health toxicity. It also includes stepwise guidance to help you to identify the hazard of your chemical being a potential mutagen or endocrine disruptor.

Start here if you want to screen for endocrine and mutagenicity or to find out how to use QSAR to determine mammalian toxicity


This page provides guidance about rapid screening tests available for human toxicity and reports some research into developing rapid screening methods using lab on a chip technology.

Start here if you cannot use QSAR methods and want to find out about rapid screeing methods for mammalian toxicity

Last Updated ( Monday, 22 June 2009 )
© 2017 REACH Regulation: Registration, Evaluation, Authorization and Restriction of Chemicals: REACH Legislation